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Hot Diagnostic Technologies: Low cost, point of care
Presenter: Mr. Paul LaBarre, Technical Officer, PATH

Hot Diagnostic Technologies: Low cost, point of care nucleic acid amplification technology which uses chemical heat to replace traditional electric heat sources. LaBarre PD1, Gerlach J1, Wilmoth J1, Beddoe A, Singleton JL1, Weigl BH1,1PATH, Seattle, WA. Many infectious diseases that impact global health are best diagnosed through pathogen-specific nucleic acid (NA) detection. However, highly accurate, disposable nucleic acid amplification tests (NAATs) are not accessible to underserved populations in low resource settings. By achieving this “first completely non-instrumented NAAT” milestone we have verified the function of the critical component of a diagnostic platform that can be used for detection of a wide selection of NAATs. This platform will be as simple to use as a pregnancy test, and is free from the traditional power requirements that constrain use of NAATS to well-equipped laboratories. We envision an extremely low cost NAAT platform that can be stockpiled indefinitely and used at the point of care (POC) with minimal training. We have achieved the first complete, non-instrumented NAAT using a calcium oxide heat source thermally linked to a proprietary phase change material (PCM). These two components alone maintain a thermal profile suitable for several isothermal NAATs which have been validated for many infectious diseases. Furthermore, we have identified and tested appropriate combinations of exothermic materials and PCMs which can be used to establish non-instrumented thermal profiles appropriate for denaturization and other isothermal diagnostic processes. These developments will enable extremely affordable POC diagnostics using accurate NAATs which, until now have required expensive, well equipped laboratory.

Contact: plabarre@path.org

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